Biocompatibilidad y actividad microbiana de sulfuro de plata nanoestructurado para aplicación en biomateriales: revisión sistemática

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Aimee Marlene Mendoza Avilés
https://orcid.org/0000-0003-4202-5276
Mercedes Guadalupe Mendoza Ornelas
https://orcid.org/0000-0002-9649-8792
Lilia Michelle Andrade Martínez
https://orcid.org/0000-0001-8050-242X
Héctor Javier Miranda Fernández
https://orcid.org/0000-0003-4375-1878
Sayra Susana Mares Muñoz
https://orcid.org/0000-0002-2466-2784
Edna Pamela Vilchis Valadez
https://orcid.org/0000-0001-7928-8817
Jesús Enrique Castañeda Cisneros
https://orcid.org/0000-0003-3167-7893
Ma. Concepción Arenas-Arrocena
https://orcid.org/0000-0002-8463-9340

Abstract

We are currently facing a difficult outlook due to the marked antibiotic resistance to existing antimicrobial agents. Microbial infections represent an important clinical threat, which is why it is necessary to look for alternatives for new agents, carrying out tests for microbial sensitivity and biocompatibility. The aim of this review is to do a systematic search about the microbial activity and the biocompatibility of silver sulfide nanostructured for biomaterial applications. The search was carried out in October 2020 in the ScienceDirect, Web of science y PubMed databases by using the keywords, biocompatibility, cell viability, antimicrobial activity or antifungal effect. The PRISMA recommendations for systematic reviews were used. From thirteen full-text articles included about in vitro or in vivo studies shown that silver sulfide nanostructures inhibited Gram (+) and Gram (-) microorganisms such as, S. aureus and E. coli, respectively, regardless of size of nanoparticles. Quantum dots smaller than 5 nm of silver sulfide presented over 65% cell viability with fibroblasts or human cells. It is concluded that the antimicrobial activity and cell viability exhibited by the silver sulfide nanostructures do not show a dependence with size and concentration, but it could be used in biomaterials.

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How to Cite
Mendoza Avilés, A. M., Mendoza Ornelas, M. G., Andrade Martínez, L. M., Miranda Fernández, H. J., Mares Muñoz, S. S., Vilchis Valadez, E. P., … Arenas-Arrocena, M. C. (2021). Biocompatibilidad y actividad microbiana de sulfuro de plata nanoestructurado para aplicación en biomateriales: revisión sistemática. Mundo Nano. Interdisciplinary Journal on Nanosciences and Nanotechnology, 14(27), 1e-14e. https://doi.org/10.22201/ceiich.24485691e.2021.27.69666
Section
Sección especial — Nano-Bio

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