Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens

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Publicado: dez. 14, 2023
Versões:
2023-12-14 (1)
DOI: https://doi.org/10.22201/ceiich.24485691e.2024.33.69813
Palavras-chave:
TiO2 nanoparticles, HOCl, antimicrobial effect, cytotoxic effect, SCAPs

Conteúdo do artigo principal

Juan Rafael Morales-Noriega
Universidad Nacional Autónoma de México, Escuela Nacional de Estudios Superiores Unidad León, León, Guanajuato, México.
https://orcid.org/0009-0007-1707-2851
Christian Andrea López-Ayuso
Universidad Nacional Autónoma de México, Programa de Doctorado en Ciencias Odontológicas, Escuela Nacional de Estudios Superiores Unidad León, Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area.
https://orcid.org/0000-0003-0534-7823
Laura Susana Acosta-Torres
Universidad Nacional Autónoma de México, Escuela Nacional de Estudios Superiores Unidad León, Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area.
https://orcid.org/0000-0002-5959-9113
Ravichandran Manisekaran
Universidad Nacional Autónoma de México, Escuela Nacional de Estudios Superiores Unidad León.
https://orcid.org/0000-0002-2934-0717

Resumo

The continuous and inappropriate use of traditionally used antimicrobial agents has caused the rise of multidrug-resistant (MDR) bacterial strains and the mutation of microorganisms in the field of dentistry. Therefore, various nanoparticles have been developed to combat resistant pathogens. Titanium dioxide (TiO2) nanoparticles have been attractive antimicrobial agents because of their chemical stability, non-toxicity, and inexpensive precursors. Therefore, TiO2-based nanodispersions were explored by preparing them with well-known antimicrobial agents, such as hypochlorous acid (HOCl), to enhance the antimicrobial effect. In this study, sol-gel-based TiO2 NPs-HOCl nanodispersions were synthesized and characterized. The antimicrobial effect was assessed by a microdilution assay using S. mutans, S. aureus,  E. faecalis, and C. albicans strains by incubating different concentrations of the nanodispersions. To evaluate the cytotoxic effects, stem cells from the apical papilla (SCAPs) were inoculated and evaluated using the MTT assay. The nanodispersion exhibited an enhanced antimicrobial effect, with almost no cytotoxicity. The HOCl-based nanodispersion exhibited a greater antimicrobial effect and high stability. Thus, it can be used as a promising antimicrobial agent for the treatment of various dental pathogens.

Detalhes do artigo

Como Citar
Morales-Noriega, J. R., López-Ayuso, C. A., Acosta-Torres, L. S., & Manisekaran, R. (2023). Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens. Mundo Nano. Revista Interdisciplinaria En Nanociencias Y Nanotecnología, 17(33), 1e-17e. https://doi.org/10.22201/ceiich.24485691e.2024.33.69813
Edição
v. 17 n. 33 (2024): 2do semestre / Nanopartículas en la industria, la medicina, la odontología y la producción de hidrógeno
Seção
Artigos de investigação

Licencia Creative Commons
Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología, editada por la Universidad Nacional Autónoma de México, se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional.
Basada en una obra en http://www.mundonano.unam.mx.

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