Bismuth subsalicylate nanoparticles by laser ablation: effect against bacteria associated with nosocomial infections Bismuth subsalicylate nanoparticles by laser ablation: effect against bacteria associated with nosocomial infections

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Published: Feb 4, 2025
Updated: 2025-02-04
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2025-02-04 (2)
DOI: https://doi.org/10.22201/ceiich.24485691e.2025.34.69835
Keywords:
Bismuth subsalicylate, Laser ablation, Antibacterial, Nosocomial bacteria

Main Article Content

Lorena Reyes-Carmona
Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases
https://orcid.org/0000-0001-8692-4877
Gina Prado-Prone
Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases
Enrique Camps
Instituto Nacional de Investigaciones Nucleares, Departamento de Física.
Argelia Almaguer-Flores
Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases

Abstract

Objective: to evaluate the antibacterial effect of bismuth subsalicylate nanoparticles (NPs-SSBi) against four bacteria, frequently associated with nosocomial infections. Methods: the NPs-SSBi were obtained in colloidal suspension by laser ablation of solids in liquids (ALSL). The size, composition, and stability of the NPs in suspension were analyzed by transmission electron microscopy and ultraviolet-visible spectroscopy. The planktonic growth and biofilm formation of two Gram-positive bacteria, S. aureus and S. epidermidis, and two Gram-negative bacteria, E. coli and P. aeruginosa, after exposure to different concentrations of NPs-SSBi (1.25 to 90 μg/mL), were evaluated by turbidity and XTT assays, respectively. Results: quasi-spherical crystalline NPs-SSBi were obtained, with a size of 4.5 ± 0.14 nm, which remain stable in colloidal suspension for at least 21 days. The NPs-SSBi inhibited the growth of all four bacteria, planktonic growth was reduced ≈80-92% at concentrations above 40 μL/mL, and biofilm formation ≈73-89% at concentrations of 80 and 90 μL/mL. Conclusions: the NPs-SSBi obtained by ALSL inhibited the growth of four important nosocomial bacteria, so they could be used for the control of health care-associated infections. 

Article Details

How to Cite
Reyes-Carmona, L., Prado-Prone, G., Camps , E., & Almaguer-Flores, A. (2025). Bismuth subsalicylate nanoparticles by laser ablation: effect against bacteria associated with nosocomial infections: Bismuth subsalicylate nanoparticles by laser ablation: effect against bacteria associated with nosocomial infections. Mundo Nano. Interdisciplinary Journal on Nanosciences and Nanotechnology, 18(34), e69835. https://doi.org/10.22201/ceiich.24485691e.2025.34.69835 (Original work published September 12, 2024)
Issue
Vol. 18 No. 34 (2025): 1er semestre / Bionanomateriales / Ravichandran Manisekaran, Verónica Campos-Ibarra, René García-Contreras, editores invitados.
Section
Research articles

Licencia Creative Commons
Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología por Universidad Nacional Autónoma de México se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional.
Basada en una obra en http://www.mundonano.unam.mx.

Author Biographies

Lorena Reyes-Carmona, Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases

Cirujana dentista y Maestra en Ciencias Médicas, Odontológicas y de la Salud por la Facultad de Odontología de la UNAM. Actualmente realiza un doctorado en Ciencias Médicas, Odontológicas y de la Salud en la UNAM. Realizó una estancia doctoral en el departamento de Química en la Universidad de Bari, Italia. Su investigación orientada al estudio de biomateriales para su potencial uso médico y odontológico.

Gina Prado-Prone, Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases

Física por la Facultad de Ciencias de la UNAM y, Maestra y Doctora en Ciencia e Ingeniería de Materiales (Biomateriales) por el Instituto de Investigaciones en Materiales, UNAM.   Realizó una estancia doctoral en el Departamento de Química de la Universidad de Boloña, Italia. Actualmente es miembro del SIN (1) y profesora de carrera titular A de tiempo completo en Laboratorio de Biointerfases de la DEPeI, Facultad de Odontología, UNAM, donde realiza investigación orientada al estudio de la funcionalización de nanomateriales para su potencial uso odontológico.

Enrique Camps , Instituto Nacional de Investigaciones Nucleares, Departamento de Física.

Licenciatura en física y Doctor en por la Universidad de la Amistad de los Pueblos, URSS. Actualmente, es parte del Sistema Nacional de Investigadores Nivel 2 y está adscrito al Departamento de Física del Instituto Nacional de Investigaciones Nucleares (ININ). Es especialista en física de plasmas y ciencia de materiales, así como en el desarrollo de nanomateriales y nanotecnología. Sus líneas de investigación incluyen aplicaciones de las radiaciones en los sectores industrial, salud y agropecuario. Es miembro de la Sociedad Mexicana de Ciencia y Tecnología de Superficies y Materiales.

Argelia Almaguer-Flores, Universidad Nacional Autónoma de México, Facultad de Odontología, Laboratorio de Biointerfases

Cirujana dentista con especialidad en Periodoncia y Doctora en Ciencias (Biología Oral), por la Facultad de Odontología de la UNAM. Realizó una estancia doctoral en el Forsyth Institute, USA, y posteriormente fue presidenta de la División Mexicana de la International Association for Dental Research (IADR). Actualmente es miembro del SNI (2), profesora de carrera titular A de tiempo completo en la DEPeI de la Facultad de Odontología de la UNAM, y responsable del Laboratorio de Biointerfases, donde se realiza investigación orientada al estudio de la interacción material-bacterias para el desarrollo de nuevos biomateriales con aplicaciones odontológicas.

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