Physiological profile of nanomaterials

Abstract

The objective of this work is to present the basis and potential application of various experimental biological models that have allowed us to know a little more about the effect of nanomaterials (NMs) when they enter and interact in a specific tissue, organ or system and, with it, establish in real time, the physiological profile of a determined nanomaterial. The results of these physiological techniques and approaches are obtained relatively fast, with relatively low cost and, provide important information related to the mechanisms of action involved in the target organ. In this review, we describe some physiological models that can provide relevant information in nano–toxicology and how they could be complemented through in silico models. Likewise, we display as an example of study associated to the biological effects induced by silver nanoparticles (AgNPs), using physiological systems such as isolated and perfused heart, isolated rings of blood vessels and respiratory tract.