Factores para considerar en el diseño y síntesis de nanopartículas poliméricas para la entrega dirigida de moléculas anticancerígenas Factors to consider in the design and synthesis of polymeric nanoparticles for targeted delivery of anticancer molecules
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Para que una molécula anticancerígena pueda ingresar a una célula tumoral y cumplir su función de manera efectiva, es esencial que supere las barreras físicas y fisiológicas impuestas por el cuerpo humano. Estas barreras deben ser consideradas, y traducidas en características fisicoquímicas específicas que la molécula debe poseer para garantizar una entrega exitosa. Una de las estrategias para mejorar la entrega de fármacos es mediante el uso de nanomateriales, los cuales sirven como transportadores para la entrega dirigida de fármacos y moléculas bioactivas. En este trabajo se revisan aspectos biológicos de relevancia para el tema que nos ocupa y cómo sintonizar/modular las propiedades fisicoquímicas del material para superar dichas barreras, permitiendo determinar el tamaño de partícula, su naturaleza química y funcionalización para direccionar la entrega del fármaco de manera más específica a las células neoplásicas. Este trabajo se enfoca en la utilización de la polimerización en emulsión como método de síntesis de nano-acarreadores, haciendo énfasis en el control del promedio y distribución de tamaño de la partícula. En cuanto a la funcionalización química, se resalta el método de funcionalización física desarrollado en nuestro grupo, dando origen a una patente.
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Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología, editada por la Universidad Nacional Autónoma de México, se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional.
Basada en una obra en http://www.mundonano.unam.mx.
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