Formación de cristales de calcio dentro del foco epiléptico de un modelo de epilepsia in vivo
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La epilepsia representa un importante problema de salud, al estimarse su afectación a 2 millones de individuos en México —los pacientes sufren más de 70 convulsiones diarias—. En el presente estudio se indujo epilepsia refractaria en ratas Wistar mediante estimulación repetida con pentilentetrazol (PTZ), de una a cien estimulaciones. El tejido del hipocampo se analizó mediante microscopía electrónica de barrido (SEM) y espectroscopía de rayos X de energía dispersiva (EDS). Se observó la formación de cristales sólidos de carbonato cálcico (CaCO3) dentro del foco epiléptico. En particular, la concentración de CaCO3 mostró una correlación directa con el número de estimulaciones, lo cual sugiere un aumento progresivo en el curso de estos eventos. Este estudio plantea una hipótesis, la cual elucida el mecanismo subyacente a la formación de cristales de CaCO3 en respuesta a las convulsiones inducidas por PTZ. Es necesario seguir investigando para determinar si existe una correlación entre la desregulación de los iones de calcio (Ca2+) en la epilepsia y la formación de CaCO3. Esta investigación abre vías para una comprensión más profunda y posibles avances en el diagnóstico de la epilepsia y los trastornos neurológicos relacionados.
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Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología, editada por la Universidad Nacional Autónoma de México, se distribuye bajo una Licencia Creative Commons Atribución-NoComercial 4.0 Internacional.
Basada en una obra en http://www.mundonano.unam.mx.
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